Click here for link to original publication. Note: At the bottom of each PDF page, be sure to click on the arrow (bottom left corner) to proceed to the next page. Copyright: c2016 Skov et al. This is an open source article distributed under the terms of the creative commons attribution license, which permits unrestricted […]
Mast Cells and Histamine in MPN Related Itching Explained
2023 Update Pepcid is one of the preferred options (H2 blocker) in combination with Zyrtec (H1 blocker) to combat itching in MPNs. This change was necessary since Zantac was taken off the market due to concerns that it contained dangerous levels of N-Nitrosodimethylamine (NDMA). NDMA is classified as a “probable human carcinogen.” Carcinogens are substances that […]
Over the Counter Combo of Zyrtec and Zantac helping PV patients get relief from Itching!
Part 1 in a New Series: “Addressing MPN Symptoms” by David Wallace 2024 Update Polycythemia vera patients suffering from intense itching have long relied on a combination of over-the-counter medications for relief, commonly known as the “Z and Z combo” – Zyrtec (cetirizine) and Zantac (ranitidine). However, in 2020, Zantac faced a widespread recall due […]
A thrombopoietin receptor antagonist is capable of depleting MF hematopoietic stem and progenitor cells
The following abstract involved the work of Dr Ron Hoffman, the principle investigator (PI), senior member of the MPN group at Mt Sinai Hospital in New York City as well as the PI of the MPN-RC. Xiaoli Wang, Phd, performed all of the lab work. Dr John Mascarenhas was my point of contact for this […]
Heidi’s MPN Story – An Increasing Trend in Patient Advocacy
by Heidi Cascarano “Watch and Wait…” What other cancer, in the 21st century, is so misunderstood that your local doctor will struggle to diagnose you, possibly tell you he has a few other patients with it, then advise you to do nothing but get a therapeutic phlebotomy and take a baby aspirin? You get online […]
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