Abstract The development of targeted therapies for the treatment of myelofibrosis highlights a unique issue in a field that has historically relied on symptom relief, rather than survival benefit or modification of disease course, as key response criteria. There is, therefore, a need to understand what constitutes disease modification of myelofibrosis to advance appropriate drug […]
Curcumin Induces Cell Death in JAK2 Mutated Cells by Inhibition of JAK2/STAT and mTORC1 Pathways
Publisher’s Note by David Wallace: The two studies below provide compelling data on the effectiveness of supplementation with curcumin in patients with MPN. Although no recent studies on curcumin have emerged in MPN (since 2019), it would seem prudent to discuss the supplement with your physician. Naturally if you are taking any type of blood […]
MPN Clinical Trials, 2022 Update
MPN Clinical Trial update with Dr. Abu-Zeinah, from ASH 2021 by David Wallace TRANSCRIPT | MPN Clinical Trials, 2022 Update David Wallace: Hello, I’m David Wallace, founder of PV Reporter and our nonprofit organization MPN Cancer Connection. And your host for today’s program, the American Society of Hematology 2021 update, is Dr. Ghaith Abu-Zeinah from […]
Jazz great Ron Miles dies due to complications from blood cancer Polycythemia Vera
Ron Miles, legendary Denver-based jazz musician, educator and prolific recording and stage artist has died at 58. His death was confirmed by his label, NY-based Blue Note Records. According to a publicist there, Miles’ manager and producer Hans Wendl said that Miles died shortly before midnight on Tuesday, March 8 at his home in Denver […]
Preclinical studies of Flonoltinib Maleate, novel JAK2/FLT3 inhibitor treatment for MPNs
Abstract Janus kinase 2 (JAK2) hyperactivation by JAK2V617F mutation leads to myeloproliferative neoplasms (MPNs) and targeting JAK2 could serve as a promising therapeutic strategy for MPNs. Here, we report that Flonoltinib Maleate (FM), a selective JAK2/FLT3 inhibitor, shows high selectivity for JAK2 over the JAK family. Surface plasmon resonance assays verified that FM had a stronger affinity […]
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