by David Wallace A new study published in the European Journal of Haematology has uncovered a significant association between blood cancers known as myeloproliferative neoplasms (MPNs) and an increased risk of dementia. This Danish population-based cohort study, spanning over two decades, provides valuable insights into the long-term neurological impacts of chronic blood cancers and inflammation […]
Theories on Treatment of Polycythemia Vera with Interferon-β
Simple Summary The myeloproliferative neoplasms (MPNs) are chronic blood cancers characterized by elevated blood cell counts and, after decades, the development of bone marrow failure. Blood clots are common and contribute massively to the symptom burden. Treatment with interferon (IFN) alpha-2 normalizes elevated blood cell counts within weeks to months. This treatment has been used […]
Inflammatory Microenvironment & Specific T-Cells in MPNs
Abstract The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by somatically acquired driver mutations in discrete genes (JAK2, CALR, MPL). In recent years, along with the advances in molecular characterization, the role of immune dysregulation has been achieving increasing relevance in the […]
Occupational and Chemical Exposure that may cause MPNs, Along with Familial Clustering
Some Jobs and Familial Clustering are Likely Suspects in Possibly developing an MPN by David Wallace The daily exposure to toxic chemicals over the span of a career may be a strong factor in leading numerous workers to develop an MPN. Certain chemicals we know are problematic, include Benzene and Toluene, as well as radiation. […]
