by Christine Kennedy Happy new year. I hope everyone will be in their best place this year. This disease has a depression end and numbers have a deep hold on us. Last year, physically and mentally, was my best year. Exercise Beats Exhaustion I started kickboxing. I think my body needed exercise. Giving in to […]
MPN Focus Fall2016 – MD Anderson Newsletter – Itching Tips, PV Reporter
The Zyrtec and Zantac combo is helping MPN patients get relief from Itching! Note: Download PDF is a small icon on the top of the gray title bar, just below.
Seven Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis
Click here for link to original publication. Note: At the bottom of each PDF page, be sure to click on the arrow (bottom left corner) to proceed to the next page. Copyright: c2016 Skov et al. This is an open source article distributed under the terms of the creative commons attribution license, which permits unrestricted […]
Mast Cells and Histamine in MPN Related Itching Explained
Updated Feb. 21, 2025 MPN patients suffering from intense itching have long relied on a combination of over-the-counter medications for relief, commonly known as the “Z and Z combo” – Zyrtec (cetirizine) and Zantac (ranitidine). However, in 2020, Zantac faced a widespread recall due to concerns over potential carcinogenic contaminants. This development left many MPN […]
Over the Counter Combo of Zyrtec and Zantac helping PV patients get relief from Itching!
Part 1 in a New Series: “Addressing MPN Symptoms” by David Wallace 2025 Update (Beta-Alanine has also been used successfully to beat itching) MPN patients experiencing severe itching have traditionally turned to a combination of over-the-counter remedies, often referred to as the “Z and Z combo,” which includes Zyrtec (cetirizine) and Zantac (ranitidine). In 2020, […]
A thrombopoietin receptor antagonist is capable of depleting MF hematopoietic stem and progenitor cells
The following abstract involved the work of Dr Ron Hoffman, the principle investigator (PI), senior member of the MPN group at Mt Sinai Hospital in New York City as well as the PI of the MPN-RC. Xiaoli Wang, Phd, performed all of the lab work. Dr John Mascarenhas was my point of contact for this […]
Heidi’s MPN Story – An Increasing Trend in Patient Advocacy
by Heidi Cascarano “Watch and Wait…” What other cancer, in the 21st century, is so misunderstood that your local doctor will struggle to diagnose you, possibly tell you he has a few other patients with it, then advise you to do nothing but get a therapeutic phlebotomy and take a baby aspirin? You get online […]
An Opportunity to improve measurement of health related quality of life symptoms using MPN Patient reported outcomes
A Patient’s Perspective – Methods to Improve MPN Research by Collecting data and Blood test results from Patients by David Wallace As a PV patient, my treatment has run a wide spectrum during the last 6 years. Starting with phlebotomy only, Hydroxyurea (short time frame), Pegasys (nearing 2 years) and now the “cutting edge combo” […]
Concomitant JAK2 V617F-positive PV and BCR-ABL-positive CML with ruxolitinib and dasatinib
Citation: Blood Cancer Journal (2015) 5, e351; doi:10.1038/bcj.2015.77 Published online 2 October 2015 March 27, 2025 update The combination of ruxolitinib and dasatinib was safe and effective in the treatment of concomitant PV and CML in this patient A Zhou1, E M Knoche1, E K Engle1, D A C Fisher1 and S T Oh1 1Division of Hematology, Washington University School of Medicine, […]
September is Blood Cancer Awareness Month
by David Wallace MPN Awareness for Blood Cancers in September Two quick items for news update: September is Blood Cancer Awareness Month, this is our time to promote MPN – Blood Cancer Awareness….be sure to post one of the many excellent images floating around on your Facebook profile (MPN Research Foundation and LLS have some […]
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