Abstract The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by somatically acquired driver mutations in discrete genes (JAK2, CALR, MPL).  In recent years, along with the advances in molecular characterization, the role of immune dysregulation has been achieving increasing relevance in the […]