Finding the right clinical trial can be a turning point in your MPN journey. Whether you have been diagnosed with polycythemia vera, myelofibrosis, essential thrombocythemia, or another myeloproliferative neoplasm, clinical trials offer access to promising new therapies before they become widely available.
Search MPN Clinical Trials: Find Open Studies for PV, Myelofibrosis, and ET
There are currently over 2,500 MPN clinical trials listed on ClinicalTrials.gov, with nearly 300 actively recruiting patients right now. That includes approximately 45 trials for polycythemia vera, 95 for myelofibrosis, and 48 for essential thrombocythemia. New trials open regularly as researchers continue to develop next-generation treatments including JAK inhibitors, interferons, BET inhibitors, and novel targeted therapies.
Our MPN Clinical Trial Finder pulls live data directly from the U.S. National Institutes of Health ClinicalTrials.gov database. You can search by MPN type, trial phase, recruitment status, location, study type, and even by specific drug names like ruxolitinib, besremi, rusfertide, or givinostat. Every result links directly to the full trial listing on ClinicalTrials.gov so you and your care team can review the complete details.
Understanding MPN Clinical Trials
Clinical trials are research studies that test new treatments, procedures, or combinations of therapies in people. For MPN patients, clinical trials have been the pathway to every major treatment advance in the past two decades, including ruxolitinib, fedratinib, pacritinib, and ropeginterferon alfa-2b.
Trials are organized by phase. Phase 1 trials test safety and dosing in a small number of patients. Phase 2 trials evaluate effectiveness and side effects in a larger group. Phase 3 trials compare the new treatment against the current standard of care in large patient populations, and Phase 4 trials gather additional data after a treatment has been approved.
Who Can Participate?
Each trial has its own eligibility criteria, which may include your specific MPN diagnosis, previous treatments, age, blood counts, and other health factors. Use the eligibility details in our trial finder to get a sense of whether you might qualify, then discuss any trials of interest with your hematologist.
Why Consider a Clinical Trial?
MPN clinical trials give you the opportunity to access cutting-edge therapies that are not yet available through standard treatment. They also allow you to play an active role in advancing research for the entire MPN community. Participation is voluntary, and your safety is monitored throughout the study by medical professionals and independent review boards.
How to Talk to Your Doctor
If you find a trial that interests you, bring the trial details to your next appointment. Your hematologist can help determine whether it is a good fit based on your diagnosis, disease status, and treatment history. Many trials also have a contact number listed that you or your doctor can call directly.
This tool is provided as a free resource by PV Reporter and MPN Cancer Connection. We update the data in real time from ClinicalTrials.gov so you always see the latest available information. If you have questions about how to use the trial finder, click the “How to Use This Tool” section below the search results.
