by David Wallace and Lou Ann Donovan Chronic inflammation is increasingly understood as a significant factor in the progression of many diseases, including Alzheimer’s and myeloproliferative neoplasms (MPNs), a group of blood cancers[1][2]. Myeloid blood cells, which are overproduced in MPNs, have been associated with Alzheimer’s disease, suggesting a link between these conditions[3]. Emerging evidence […]
Impact of JAK-inhibitor therapy on inflammation-mediated comorbidities in MPNs
by Dr. Hans C Hasselbalch Chronic inflammation is suggested to contribute to the Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) disease initiation and progression, as well as the development of premature atherosclerosis and may drive the development of other cancers in MPNs, both nonhematologic and hematologic. The MPN population has a substantial comorbidity burden, including cerebral, cardiovascular, pulmonary, abdominal, […]
